.Attribute Medicine, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and also epidemiologic evaluations uncovered that an unfamiliar reassortant virus-like family tree of the Oropouche infection, which has been spreading in the western Amazon.com area of Brazil for about a decade, is associated with the latest individual outbreaks in between 2022 and also 2024.